Method of inactivating microorganisms
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United States of America Patent
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Jan 6, 2004
Grant Date -
Feb 20, 2003
app pub date -
Sep 19, 2002
filing date -
Dec 20, 1999
priority date (Note) -
Expired
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Abstract
This invention provides methods of inactivating a microorganism and preparing a vaccine including the step of applying to said microorganism a cross-linking agent simultaneously with a separate inactivant. This invention further relates to vaccines prepared by such methods and a kit including such inactivated microorganism. The cross-linking agent is typically formaldehyde (FA) and the inactivant typically binary ethyleneimine (BEI).
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