Amination process
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United States of America Patent
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Dec 30, 2003
Grant Date -
Sep 12, 2002
app pub date -
Mar 7, 2001
filing date -
Mar 7, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention provides methodology for carbon-nitrogen bond formation via vinyl or aryl amination. In the process of the invention, an sp.sup.2 hybridized radical is reacted with an azomethine moiety to form pyrrolidine and indole compounds. The methodology provides a facile process for the synthesis of compounds having the pyrrolidine or indole subunit and is especially advantageous for compounds having acid or base labile functional groups and/or is comprised of chiral centers susceptible to acid/base epimerization.
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