Water-soluble amide derivatives of polyene macrolides and preparation and uses thereof
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United States of America Patent
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Dec 16, 2003
Grant Date -
Feb 27, 2003
app pub date -
May 29, 2001
filing date -
May 31, 2000
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Expired
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Abstract
The present invention provides two new classes of polyene macrolide amide derivatives useful for treating or preventing fungal infections. The new polyene macrolide amide derivatives exhibit antifungal activity and are more water-soluble than conventional polyene antibiotics, such as amphotericin B and amphotericin B methyl ester.
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