Multiple portion tablet
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United States of America Patent
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Dec 16, 2003
Grant Date -
N/A
app pub date -
Aug 19, 2002
filing date -
Aug 19, 2002
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A solid orally administrable pharmaceutical dosage form for the treatment of gastric disorders includes a first portion containing a therapeutically effective amount of a histamine H.sub.2 -receptor antagonist, and a second portion immediately adjacent the first portion without an intervening barrier disposed between the first portion and the second portion, the second portion containing a therapeutically effective amount of an antacid. Physical separation of the active ingredients into two different portions without a separating barrier has been found sufficient to prevent degradation of the histamine H.sub.2 -receptor antagonist due to contact with the antacid. The invention therefore provides stabilization of a histamine H.sub.2 -receptor antagonist-antacid combination tablet which is comparable to known multiple portion tablets, but without an intervening barrier between the antacid portion and the histamine H.sub.2 -receptor antagonist portion. Therefore, the benefits of the prior art are achieved at a reduced cost by eliminating a barrier and manufacturing steps associated with the provision of a barrier, as is conventional.
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