Aqueous liposome system and a method for the preparation of such a liposome system
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United States of America Patent
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Dec 16, 2003
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N/A
app pub date -
Mar 7, 1996
filing date -
Mar 15, 1993
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Abstract
An aqueous liposome system comprises at least one phospholipid, a non-phospholipidic substance which is a bile acid or derivative thereof, and, optionally, a non-toxic organic solvent. The mass ratio of phospholipid to the non-phospholidic substance is in the range between 1:0.001 and 1:0.1. The diameter of the liposomes formed in this liposome system is in the range between 35 and 90 nm. The liposome system is stable over large periods of time, e.g., several months or years, and is highly transparent. The liposomes may be loaded with a pharmaceutically active ingredient.
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