2,4,6-trisubstituted-pyrimidine compounds
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United States of America Patent
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Dec 9, 2003
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N/A
app pub date -
Jul 10, 2002
filing date -
Nov 30, 2001
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Abstract
This invention features pyrimidine compounds of formula (I): ##STR1## R.sub.1 is ##STR2## each of R.sub.2 and R.sub.4 is H; R.sub.3 is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl; R.sub.5 is H or alkyl; n is 0, 1, 2, 3, 4, 5, or 6; X is NR.sup.c ; Y is covalent bond, CH.sub.2, C(O), C.dbd.N--R.sup.c, C.dbd.N--OR.sup.c, C.dbd.N--SR.sup.c, O, S, S(O), S(O.sub.2), or NR.sup.c ; Z is N or CH; one of U and V is N, and the other is CR.sup.c ; and W is O, S, S(O), S(O.sub.2), NR.sup.c, or NC(O)R.sup.c ; in which each of R.sup.a and R.sup.b, independently, is H, alkyl, aryl, heteroaryl; and R.sup.c is H, alkyl, aryl, heteroaryl, cyclyl, heterocyclyl, or alkylcarbonyl.
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