Treatment of intracellular infection
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United States of America Patent
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Dec 9, 2003
Grant Date -
N/A
app pub date -
Nov 20, 2001
filing date -
Apr 9, 1999
priority date (Note) -
Expired
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Abstract
An agent for combating an intracellular microbial infection comprises a phage component and, associated therewith, a targeting moiety which directs the agent to a target cell and initiates delivery of the phage into the target cell. Once inside the target cell, the phage causes lysis of a microorganism residing within the target cell. A mycobacteriophage is combined with a targeting moiety of transferrin. Compositions comprising the agent, methods of preparing said agent, and use of said agent for combating intracellular infections are also provided.
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