Induction of a Th1-like response in vitro
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United States of America Patent
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Dec 2, 2003
Grant Date -
Mar 13, 2003
app pub date -
Oct 9, 2002
filing date -
Jul 8, 1999
priority date (Note) -
Expired
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Abstract
The invention provides compositions and methods for stimulating a Th1-like response in vitro. Compositions include fusion proteins and conjugates that contain at least a portion of a heat shock protein. A Th1-like response can be elicited by contacting in vitro a cell sample containing naive lymphocytes with a fusion protein or conjugate of the invention. The Th1-like response can be detected by measuring IFN-gamma produced by the cell sample.
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