Modified carboxypeptidase enzymes and their use
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United States of America Patent
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Dec 2, 2003
Grant Date -
Jul 11, 2002
app pub date -
Jul 5, 2001
filing date -
Jul 7, 2000
priority date (Note) -
Expired
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Abstract
The invention relates to improvements relating to cancer therapy based on the identification of a number of regions of CPG2 which contain epitopes which appear to be involved in the production of a host immune response and which may be modified to alter the immunogenicity in patients. Production of fusions of CPG2 with an antibody, where the CPG2 protein has been tagged provides a CPG2 protein which has reduced immunogenicity. By using partially glycosylated enzyme obtainable by P. pastoris expression, the efficacy of antibody-CPG2 fusions is enhanced.
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