Compounds and methods for modulating activation of NF-.kappa.B
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United States of America Patent
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Dec 2, 2003
Grant Date -
Sep 4, 2003
app pub date -
Apr 9, 2001
filing date -
Dec 10, 1998
priority date (Note) -
Expired
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Abstract
Compositions and methods for modulating the activation of nuclear factor .kappa.B (NF-.kappa.B) are provided. The compositions comprise one or more agents that modulate ubiquitination of phosphorylated I.kappa.B.alpha. and/or I.kappa.B.beta.. Such compositions may be used for treating diseases associated with NF-.kappa.B activation. Modulating agents include human E3 ubiquitin ligases, antibodies thereto and variants thereof, as well as related proteins.
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