Spliced gene of KSHV / HHV8, its promoter and monoclonal antibodies specific for LANA2
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United States of America Patent
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Nov 25, 2003
Grant Date -
Sep 26, 2002
app pub date -
Dec 8, 2000
filing date -
Dec 8, 2000
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Abstract
This invention provides an isolated nucleic acid which encodes a Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 2 polypeptide (LANA2) or a fragment thereof and also provides the LANA2 polypeptide. This invention provides an isolated nucleic acid comprising consecutive nucleotides having the sequence of a promoter of Kaposi's sarcoma-associated herpesvirus latency-associated nuclear antigen 2 transcription. This invention also provides a method of inhibiting p53 mediated apoptosis of a cell and a method of producing an antibody which comprises introducing into a cell a replicable vector of the subject invention.
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