Methods of preparing amino acid taxane derivatives and polymer conjugates containing the same
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Nov 18, 2003
Grant Date -
N/A
app pub date -
Sep 20, 2002
filing date -
Sep 20, 2002
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
Methods of preparing amino acid-substituted taxanes such as: ##STR1## using selected blocked amino acids are disclosed. After coupling of the blocked amino acid to the taxane, deprotection is carried out with about an equimolar amount of a secondary amine thus substantially avoiding base-catalyzed hydrolysis of amino acid from the taxane. The preferred amino acid-taxanes are useful as intermediates in the production of polymer conjugated therapeutic compositions or as part of pharmaceutically acceptable formulations.
First Claim
Family
International Classification(s)
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully