Process of lactonization in the preparation of statins
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United States of America Patent
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Nov 18, 2003
Grant Date -
Mar 13, 2003
app pub date -
Jul 23, 2002
filing date -
Aug 27, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention relates to a process for preparing lovastatin and simvastatin which comprises (1) performing step of a lactonization of mevinic acid and analog thereof compounds in the presence of a dehydrating agent and without an acid catalyst under nitrogen sweep; and then (2) making step of crystals at a high temperature. In the process of the present invention, lovastatin and simvastatin highly purified can be produced in a high yield and especially, heterodimers formed as a by-product can be reduced in an amount remarkably. Therefore, the process of the present invention is convenient and economical.
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