Process for the synthesis of chloropurine intermediates
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United States of America Patent
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Nov 11, 2003
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N/A
app pub date -
Apr 25, 2000
filing date -
Oct 14, 1997
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Abstract
The present invention relates to a process for the preparation of a carbocyclic purine nucleoside analogue of formula (I), its salts and pharmaceutically acceptable derivatives thereof which comprises hydrolysing a compound of formula (IV) wherein P is a protecting group, in the presence of an acid, condensing the product of formula (V) formed in situ in the presence of a base with a compound of formula (VI) followed by in situ ring closure of the resulting intermediate.
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