Erythropoietin liposomal dispersion
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United States of America Patent
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Nov 11, 2003
Grant Date -
Mar 7, 2002
app pub date -
Feb 18, 1999
filing date -
Feb 23, 1998
priority date (Note) -
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Abstract
The present invention relates to a liposome based formulation of erythropoietin comprising: (a) an effective amount of an erythropoietin; (b) a lipidic phase comprising: (i) lecithin or hydrogenated lecithin; (ii) optionally, a charged electropositive or electronegative lipid compound; and (iii) cholesterol or a derivative thereof selected from cholesterol esters, polyethylene glycol derivatives of cholesterol (PEG-cholesterols), and organic acid derivatives of cholesterols; and (c) a phosphate buffer. The liposome based parenteral dosage form of the invention is prepared by means of an ethanol injection technique. The composition avoids the need for use of human serum albumin and exhibits superior stability.
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