Process for the synthesis of beta-lactam derivatives
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United States of America Patent
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Nov 4, 2003
Grant Date -
N/A
app pub date -
Mar 13, 2002
filing date -
Jul 27, 1999
priority date (Note) -
Expired
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Abstract
The invention is directed towards a process for the preparation of Cefuroxime acid or for a corresponding pharmaceutically acceptable salt or ester. The process comprises the carbamoylation of a Cefuroxime precursor with an activated isocyanate. Additionally, the process is characterized by the fact that a carbonic C.sub.1 -C.sub.4 alkyl ester is used as a solvent for the carbamoylation reaction.
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