Process for making morphine-6-glucuronide and its analogues using haloglucuronate ester intermediates
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United States of America Patent
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Nov 4, 2003
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N/A
app pub date -
Jun 7, 2002
filing date -
Jun 21, 1999
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Expired
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Abstract
A process for manufacturing morphine-6-glucuronide and related compounds of the general structure of Formula 1: ##STR1## wherein optionally substituted morphine is conjugated with an optionally substituted member of a new class of intermediates, namely, 1-haloglucuronate esters, in the presence of iodine or an iodinium compound. The conjugation may be followed by conversion of R.sup.1 of Formula 1 into hydrogen and/or the removal of the ester groups from the glucuronic residue at R.sup.2 of Formula 1.
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