Yohimbine dimers exhibiting binding selectivities for .alpha.2 adrenergic receptors
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United States of America Patent
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Oct 28, 2003
Grant Date -
Feb 20, 2003
app pub date -
Mar 25, 2002
filing date -
Mar 23, 2001
priority date (Note) -
Expired
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Abstract
The present invention relates to yohimbine dimer compounds, pharmaceutical compositions containing such dimer compounds, methods of making such dimer compounds, and uses thereof. The yohimbine dimer compounds include compounds of formula (I): ##STR1## where R is any linker molecule which affords a yohimbine dimer that has activity as an .alpha..sub.2 -AR antagonist and has selectivity for an .alpha..sub.2 -AR subtype over another .alpha..sub.2 -AR subtype.
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