Antiviral purine derivatives
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United States of America Patent
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Oct 28, 2003
Grant Date -
Oct 18, 2001
app pub date -
Mar 27, 2001
filing date -
Sep 28, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Compounds of the formula ##STR1## wherein Ar is aryl, R.sup.1 and R.sup.2 are hydrogen alkyl, alkyl substituted with phenyl, and aryl, O, NH, NR.sup.4 and S, R.sup.5 is hydrogen, alkyl or aryl or alkylene when taken with R.sup.1, and R.sup.3 is hydrogen, alkyl, alkyl substituted with phenyl, aryl, a heterocyclic group or a polycyclic group, are antiviral agents. A typical embodiment is (1S,4R)-4-[2-amino-6-(cyclopropylamino)-9H-purin-9-yl]-2-cyclopentene-1-methanol O-[phenyl-(methoxy-L-alaninyl)]phosphate.
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