Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (ADP-ribose) glycohydrolase, and methods for their use
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United States of America Patent
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Oct 21, 2003
Grant Date -
Sep 19, 2002
app pub date -
Apr 10, 2001
filing date -
Jan 16, 2001
priority date (Note) -
Expired
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Abstract
Symmetrically disubstituted aromatic compounds and pharmaceutical compositions containing such compounds that inhibit and/or modulate the activity of poly(ADP-ribose) glycohydrolase, also known as PARG, are described. The invention is also directed to the therapeutic or prophylactic use of such compounds and compositions, and to methods of treating diseases and disorders described herein, by administering effective amounts of such compounds.
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