Cryopreservation system with controlled dendritic freezing front velocity
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United States of America Patent
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Oct 21, 2003
Grant Date -
Nov 28, 2002
app pub date -
May 22, 2001
filing date -
May 22, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A biopharmaceutical material cryopreservation system is provided that includes a flexible sterile container comprising a biocompatible polymeric material. The flexible sterile container contains biopharmaceuticals materials for freezing and cryopreservation. A freezing system is thermally coupled to the biopharmaceutical materials via the flexible sterile container. The freezing system comprises a temperature sensor that monitors a temperature of the biopharmaceutical materials. Also, the freezing system comprises a feedback loop constructed to control a dendritic freezing front velocity, within the biopharmaceutical materials, in a range from approximately 5 millimeters per hour to approximately 250 millimeters per hour based on feedback information from the temperature sensor.
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