Gastric retaining oral liquid dosage form
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United States of America Patent
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Oct 21, 2003
Grant Date -
Jan 23, 2003
app pub date -
Dec 22, 1999
filing date -
Dec 23, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The present invention is directed to an active agent dosage form which is adapted for retention in the stomach and useful for the prolonged delivery of a liquid, active agent formulation to a fluid environment of use. The liquid, active agent formulation is sorbed into porous particles that are dispersed in a polymer matrix that swells upon contact with the fluids of the stomach. A portion of the polymer matrix may be surrounded by a band of insoluble material that prevents the covered portion of the polymer matrix from swelling and provides a segment of the dosage form that is of sufficient rigidity to withstand the contractions of the stomach and delay expulsion of the dosage form from the stomach until substantially all of the active agent has been dispensed.
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