5'-modified nucleotides and the application thereof in molecular biology and medicine
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United States of America Patent
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Sep 30, 2003
Grant Date -
N/A
app pub date -
Jan 10, 2001
filing date -
Apr 8, 1998
priority date (Note) -
Expired
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Abstract
The invention relates to 5'-modified nucleotides and to nucleic acids which contain these nucleotides. Processes for incorporating the 5'-modified nucleotides into nucleic acids, and the subsequent site-specific cleavage of the nucleic acids at the 5'-modified monomer building blocks, are also disclosed. These processes can be employed for nucleic acid sequencing, for generating nucleic acid libraries, for detecting mutations, for preparing support-bound nucleic acids and for pharmaceutical purposes.
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