Liposome extrusion process
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United States of America Patent
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Sep 23, 2003
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N/A
app pub date -
Nov 20, 2001
filing date -
Oct 5, 1990
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Expired
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Abstract
A method of sizing liposomes by passing a suspension of liposomes through an aluminum oxide porous film by entering the film via the smaller pores and extruded via the larger pores, under pressure, is disclosed. In a preferred embodiment, the porous film is a branched-pore type anodic aluminum oxide porous film. The process produces a population of liposomes substantially free of liposomes above a predetermined maximum size. Also disclosed is an apparatus for carrying out the invention.
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