2-arylquinoline derivatives, preparation and therapeutic use thereof

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United States of America Patent

PATENT NO 6617336
SERIAL NO

10130875

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Abstract

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Compounds of general formula (I) ##STR1## in which: A represents a hydrogen atom, a hydroxyl, a C.sub.1-3 alkoxy group, a hydroxy(C.sub.1-6 alkyl) group, a (C.sub.1-3 alkoxy)(C.sub.1-3 alkyl) group, a thiol, (C.sub.1-6 alkyl)sulfanyl or a halogen; B and D represent, independently of one another, a hydrogen atom, a C.sub.1-6 alkyl group, a fluoro(C.sub.1-6 alkyl) group or a perfluoro(C.sub.1-2 alkyl) group or B and D together from an oxo; R.sub.1 represents a phenyl, a naphthyl or a heteroaryl comprising 4 or 5 carbon atoms; R.sub.2 and R.sub.3 represent, independently of one another, a hydrogen atom, a halogen or a C.sub.1-6 alkyl group, R.sub.4 represents a hydrogen atom, a hydroxyl or a halogen, and R.sub.5 and R.sub.6 represent, independently of one another, a hydrogen atom, a C.sub.1-6 alkyl group, a C.sub.2-6 alkenyl group, a C.sub.3-6 cycloalkyl group, a C.sub.3-6 cycloalkenyl group, a fluoro(C.sub.1-6 alkyl) group or a perfluoro(C.sub.1-2 alkyl) group or R.sub.5 and R.sub.6 together form a C.sub.2-6 alkylene chain or a C.sub.3-6 alkenylene chain, to give, with the nitrogen to which they are attached, a heterocycle, this heterocycle optionally being substituted by a C.sub.1-4 alkyl group; and their salts.

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Patent Owner(s)

Patent OwnerAddress
SANOFI-SYNTHELABO174 AVENUE DE FRANCE F-75013 PARIS

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Bovy, Philippe R Mareil Marly, BG 35 245
Braun, Alain Boulogne Billancourt, FR 11 97
Philippo, Christophe Rueil-Malmaison, FR 19 279

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