Preparation and drug composition of bis-benzyl-isoquinoline class alkaloids
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United States of America Patent
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Sep 9, 2003
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May 2, 2002
filing date -
May 2, 2002
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Abstract
This invention relates to the preparation of bis-isoquinoline derivatives of general formula (I) and salts thereof, which possesses multi-drug resistance (MDR) reversal activities. Drug compositions and formulations comprising bis-isoquinoline derivatives of general formula (I) and salts thereof are provided for use as sensitivity enhancers in cancer chemotherapy. Methods for inhibiting MDR by treatment with bis-isoquinoline derivatives are also provided.
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