Sustained release ranolazine formulations

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United States of America Patent

PATENT NO 6617328
SERIAL NO

10259143

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Abstract

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A sustained release ranolazine formulation contains an intimate mixture of ranolazine and a partially neutralized pH-dependent binder to form a film that is mostly insoluble in aqueous media below pH 4.5 and soluble in aqueous media above pH 4.5. The formulation is suitable for twice daily administration of ranolazine and is useful for controlling the rate of dissolution of ranolazine, and to maintain human plasma ranolazine levels at between 550 and 7500 ng base/mL.

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Patent Owner(s)

Patent OwnerAddress
GILEAD SCIENCES INC333 LAKESIDE DRIVE FOSTER CITY CA 94404

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Baker, Fiona Dunfermline, GB 13 73
Langridge, John Wrexham, GB 7 93
Wolff, Andrew A San Francisco, CA 24 216

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