Method for producing a pyranosyl nucleic acid conjugate
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United States of America Patent
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Sep 2, 2003
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N/A
app pub date -
Mar 20, 2000
filing date -
Sep 22, 1997
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Abstract
The invention relates to a process for the preparation of a pyranosyl nucleic acid of the formula (I) or of the formula (II) ##STR1## The process for the preparation of the pyranosyl nucleic acid comprises (a) bonding the nucleoside to a solid support, (b) deprotecting the 3',4'-protected nucleoside, (c) reacting the reaction product from step (b) with a 3',4'-protected pyranosyl nuceloside phosphoramidite, repeating steps (b) and (c) one or more times to produce the desired length of nucleic acid, and coupling a biomolecule to the product of step (d). In a further step, the nucleic acid can be released from the solid support. In one embodiment, the biomolecule may be a DNA or RNA, where furanosyl nucleoside phosphoramidites are added to the pyranosyl nucleic acid.
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