Insulin C-peptides
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United States of America Patent
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Aug 26, 2003
Grant Date -
Aug 8, 2002
app pub date -
Jul 8, 1999
filing date -
Sep 27, 1996
priority date (Note) -
Expired
status (Latency Note)
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Abstract
The invention features peptides that are fragments of the human insulin C-peptide, which peptides include the sequence ELGGGPGAG or a fragment thereof, or the sequence EGSLQ or a fragment thereof. The peptides have the ability to stimulate Na.sup.+ K.sup.+ ATPase activity. Also provided are biomimetic organic compounds exhibiting activation of Na.sup.+ K.sup.+ ATPase activity and/or cellular binding to renal tubule cells and fibroblasts. Such peptides and compounds are useful in combating diabetes and diabetic complications, or for stimulating Na.sup.+ K.sup.+ ATPase activity.
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