IL-8 receptor antagonists
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United States of America Patent
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Aug 12, 2003
Grant Date -
N/A
app pub date -
May 16, 2002
filing date -
Nov 25, 1999
priority date (Note) -
Expired
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Abstract
The present invention relates to novel compounds which inhibit the action of CXC chemokines, such as IL-8, Gro, NAP-2, ENA-78 etc., on their receptors, to the process for their preparation and to their use for obtaining drugs. According to the invention, said compounds are novel indole derivatives selected from the group consisting of: i) the products of the formula ##STR1## in which: X is a double bond --C.dbd.C-- or a sulfur atom; R.sub.1 is a halogen, a nitro group, a trifluoromethyl group or a C.sub.1 -C.sub.3 alkyl group; R.sub.2, R.sub.3 and R.sub.4 are each independently a hydrogen atom, a halogen, a C.sub.1 -C.sub.3 alkyl group, a nitro group, a trifluoromethyl group or a cyano group, or R.sub.2 and R.sub.3 form a fused aromatic ring together with the aromatic ring to which they are attached; and n is equal to 2 or 3; and ii) esters of the compounds of formula I and addition salts of said compounds with a mineral or organic base.
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