Adenosine receptor antagonists and methods of making and using the same
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United States of America Patent
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Aug 12, 2003
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N/A
app pub date -
Nov 13, 2000
filing date -
Nov 12, 1999
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Expired
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Abstract
The invention is based on the discovery that compounds of Formula I are unexpectedly highly potent and selective inhibitors of the adenosine A.sub.1 receptor. Adenosine A.sub.1 antagonists can be useful in the prevention and/or treatment of numerous diseases, including cardiac and circulatory disorders, degenerative disorders of the central nervous system, respiratory disorders, and many diseases for which diuretic treatment is suitable. In one embodiment, the invention features a compound of formula I: ##STR1## R.sub.3 is an optionally substituted group selected from: ##STR2## ##STR3## and wherein X.sub.1, X.sub.2, Z, R.sub.1, R.sub.2, and R.sub.6 are as described in the specification.
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