Method of detecting inhibitors of agonist-specific desensitization
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United States of America Patent
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Aug 12, 2003
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N/A
app pub date -
May 11, 2000
filing date -
Apr 24, 1989
priority date (Note) -
Expired
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Abstract
The present invention relates to a method of inhibiting desensitization of a cell to the effects of a compound. The method comprises contacting the cell with an agent capable of inhibiting phosphorylation, by a protein kinase, of a receptor for the compound present on the surface of the cell. The present invention also relates to a method of screening a compound for its ability to inhibit desensitization. The method comprises: i) contacting a receptor specific kinase-containing sample with the compound under conditions such that interaction between receptor specific kinase present in the sample and the compound can occur, and ii) determining the ability of the receptor specific kinase to phosphorylate the receptor for which it is specific.
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