Receptor structures
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United States of America Patent
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Aug 5, 2003
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N/A
app pub date -
Apr 14, 2000
filing date -
Apr 19, 1999
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Abstract
The present invention relates to modified polypeptide derivatives of the B domain or Z domain of staphylococcal protein A (SPA). The derivatives contain amino acid substitutions that result in the ability of the B domain or Z domain to interact with at least one domain of a human Factor VIII protein, without substantially disrupting the structure and stability of the B domain or Z domain.
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