Basic peptides and pharmaceutical compositions containing same
Number of patents in Portfolio can not be more than 2000
United States of America Patent
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Aug 5, 2003
Grant Date -
N/A
app pub date -
Feb 23, 2001
filing date -
Aug 24, 1998
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Abstract
The present invention relates to an NST300 compound of general formula (I): comprising the following components: X1--[(X3)a/(X4)b] in which X1 represents a fatty acid or prenyl group; and X3 represents a domain of positively charged amino acids; and X4 represents a domain containing aromatic amino acids; and a stands for an integer of 1-8; and b stands for an integer of 1-8. The invention relates also to pharmaceutical compositions comprising a compound of general formula (I), the use of the compound and of the pharmaceutical composition in the preparation of a medicament and in methods for the treatment or prevention of prothrombic states in disorders which are associated with excessive procoagulant activity, initiated or propagated by CMLA loss. The invention relates also to the use of the compound and of the pharmaceutical composition for the diagnosis of CMLA loss; as a targeting agent; as targeting drugs to tissues inflicted by CMLA loss; and for basic research in fields of research in which CMLA loss takes place both in vitro and in vivo.
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