Stable factor VIII compositions
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United States of America Patent
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Jul 29, 2003
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app pub date -
Jul 12, 2000
filing date -
Jul 13, 1999
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Abstract
The present invention relates to a pharmaceutical composition comprising Factor VIII and the divalent metal ions Zn.sup.2+ and Cu.sup.2+, optionally in the presence of Ca.sup.2+ ions and/or Mn.sup.2+ ions, wherein said Factor VIII is stable without the addition of albumin. The invention also relates to a method for the production of recombinant Factor VIII from mammalian cells carrying the gene therefor, comprising culturing said mammalian cells in medium free of plasma-derived protein and supplemented with divalent metal ions, including Cu.sup.2+ and Zn.sup.2+, and optionally in the presence of Ca.sup.2+ and Mn.sup.2+ ions.
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