Cinnamoyl distamycin analogous derivatives, process for their preparation, and their use as antitumor agents
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United States of America Patent
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Jul 22, 2003
Grant Date -
N/A
app pub date -
Dec 4, 2000
filing date -
Jun 5, 1998
priority date (Note) -
Expired
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Abstract
Compounds which are cinnamoyl distamycin derivatives of formula (I), wherein n is 2, 3, or 4; R.sub.0 is C.sub.1 -C.sub.4 alkyl or C.sub.1 -C.sub.3 haloalkyl; R.sub.1 and R.sub.2, which are the same or different, are selected from hydrogen, C.sub.1 -C.sub.4 alkyl optionally substituted by one or more fluorine atoms; and C.sub.1 -C.sub.4 alkoxy; X is a halogen atom; Y and Z are the same or different and are selected, independently for each heterocyclic ring of the polyheterocyclic chain, from N and CH; B is selected from (a), (b), (c), (d), (e), (f), (g)and (h) wherein R.sub.3, R.sub.4, R.sub.5, R.sub.6 and R.sub.7 are, independently from each other, hydrogen or C.sub.1 -C.sub.4 alkyl; or pharmaceutically acceptable salts thereof; provided that at least one of the heterocyclic rings within the polyheterocyclic chain is other than pyrrole; are useful as antitumor agents.
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