Method of obtaining extracellular and intracellular pH images and spectra by magnetic resonance using extrinsic indicators containing 1H or 19F
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United States of America Patent
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Jul 22, 2003
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Jun 7, 2000
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Mar 6, 1997
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Abstract
The present invention refers to the use of a selection of imidazole compounds in a method of obtaining extracellular or intracellular pH images in biological systems, by magnetic resonance, consisting of administering the imidazole compound to said biological system and acquiring a pH image through magnetic resonance measurements, and said method selected from the group consisting of proton magnetic resonance chemical shift imaging (.sup.1 H CSI), proton magnetic resonance spectroscopic imaging (.sup.1 H MRSI), fluorine magnetic resonance chemical shift imaging (.sup.19 F CSI), fluorine magnetic resonance spectroscopic imaging (.sup.19 F MRSI), and combinations thereof.
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