Generation of pharmaceutical agent particles using focused acoustic energy
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United States of America Patent
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Jul 22, 2003
Grant Date -
Oct 3, 2002
app pub date -
Mar 30, 2001
filing date -
Mar 30, 2001
priority date (Note) -
Expired
status (Latency Note)
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Abstract
A method and device for generating pharmaceutical agent particles using focused acoustic energy are provided. A solution of the pharmaceutical agent is provided in a solvent, which may be an aqueous fluid, a nonaqueous fluid, or a supercritical fluid. Focused acoustic energy is used to eject a droplet of the solution, which is then directed into or through an antisolvent that upon admixture with the solution droplet causes the pharmaceutical agent in the droplet to precipitate. In a preferred embodiment, the solvent is an aqueous or organic liquid, and the antisolvent is a supercritical fluid.
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