Bis-benzazoles and their use as antineoplastic agents
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United States of America Patent
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Jul 8, 2003
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N/A
app pub date -
Apr 18, 2002
filing date -
Apr 16, 1999
priority date (Note) -
Expired
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Abstract
'Head-to-head' bis-benzimidazoles having the following formula ##STR1## wherein A.sup.1, A.sup.2, X.sup.1 and X.sup.2 are as defined in the following specification, have been found to bind to specific sequences in the minor groove of duplex DNA, and to have cytotoxic effects against a range of tumor cell lines.
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