Heat treatment for viral inactivation
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United States of America Patent
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Jul 1, 2003
Issued Date -
N/A
app pub date -
Dec 1, 1997
filing date -
Jun 26, 1987
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Heat treatment apparatus for inactivating viruses in blood products includes a series of tubing coils with connectors at the opposite ends of the series for connecting the tubing to a blood product source and a blood product destination. The apparatus also includes a microwave heating chamber arranged to receive the first coil of the series and a cooling chamber adapted to receive the second coil of the series. Microwave energy is supplied to the heating chamber for heating the blood product as it flows along the first coil from an initial temperature to an elevated temperature and the cooling chamber is cooled so that the blood product in the second coil is cooled to a selected temperature appreciably below the elevated temperature. A radiometer circuit is provided for monitoring the temperatures of the blood product in the first and second coils to produce first and second temperature signals in response thereto. A controller responds to these temperature signals by controlling the energy producing means to impart a selected time/temperature profile to the blood product flowing through the tubing and to deliver that product at a selected delivery temperature. A third coil and a second heating chamber may be provided to heat the blood product to the delivery temperature following the cooling thereof.
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