Acetylcholine enhancers
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United States of America Patent
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Jul 1, 2003
Grant Date -
Nov 8, 2001
app pub date -
Apr 17, 2001
filing date -
Jun 10, 1998
priority date (Note) -
Expired
status (Latency Note)
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Abstract
Disclosed herein are quinoline derivatives having dual mechanistic properties, referred to in this patent document as 'acetylcholine enhancers', i.e., compounds which evidence acetylcholinesterase (AChE) inhibition activity, and 5-HT3 receptor antagonist activity. A particularly preferred compound is 2-[2-(1-benzylpiperizin-4-yl)ethyl]-2,3-dihydro-9-methoxy-1H-pyrrolo [3,4-b] quinolin-1-one hemifumarate, referred to herein as Compound A ('Cm.A').
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