Importance

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Abstract

A compound having formula (I), wherein R is selected from the group comprising C.sub.5 to C.sub.20 alkyl, C.sub.5 to C.sub.20 cycloalkyl, halogens, aryl and alkylaryl; R' is selected from the group comprising hydrogen, alkyl, cycloalkyl, halogens, amino, alkylamino, dialkylamino, nitro, cyano, alkyoxy, aryloxy, thiol, alkylthiol, arythiol, alkyl; R' is selected from the group comprising hydrogen, alkyl, cycloalkyl, halogens, alkyloxy, aryloxy and aryl; Q is selected from the group comprising O, S and CY.sub.2, where Y may be the same or different and is selected from H, alkyl and halogens; X is selected from the group comprising O, NH, S, N-alkyl, (CH.sub.2).sub.n where n is 1 to 10, and CY.sub.2 where Y may be the same or different and is selected from hydrogen, alkyl and halogens; Z is selected from the group comprising O, S, NH, and N alkyl; U' is H and U' is selected from H and CH.sub.2 T, or U' and U' are joined so as to form a ring moiety including Q wherein U'-U' together is respectively selected from the group comprising --CTH--CT'T'-- and --CT.dbd.CT-- and --CT'.dbd.CT'--, so as to provide ring moieties selected from the group comprising formula (II) and (III) wherein T is selected from the group comprising OH, H, halogens, O-alkyl, O-acyl, O-aryl, CN, NH.sub.2 and N.sub.3 ; T' is selected from the group comprising H and halogens and where more than one T' is present they may be the same or different; T' is selected from the group comprising H and halogens, and W is selected from the group comprising H, a phosphate group and a pharmacologically acceptable salt, derivative or prodrug thereof shows potent anti-viral activity against, for example, varicella zoster virus and cytomegalovirus. ##STR1##

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First Claim