Process for viral inactivation of lyophilized blood proteins
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United States of America Patent
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May 20, 2003
Grant Date -
Nov 29, 2001
app pub date -
Jun 28, 2001
filing date -
Apr 19, 1996
priority date (Note) -
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Abstract
A process for inactivating viral contaminants of lyophilized Factor VIII by heat is provided. The process comprises forming a stable complex between the Factor VIII and a cyclodextrin in an aqueous solution. The solution is then lyophilized, and the Factor VIII/cyclodextrin complex is recovered. The lyophilized Factor VIII/cyclodextrin is then heated to 60.degree. C. to inactivate any virus present. The material may then be reconstituted prior to administration to a patient.
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