Synthetic peptides of type II collagen for cartilage resorption assays
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United States of America Patent
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May 20, 2003
Grant Date -
Dec 5, 2002
app pub date -
Feb 11, 2002
filing date -
Jun 19, 1998
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Abstract
The claimed invention is peptides synthesized to match telopeptide components of type II collagen degradation products in synovial fluid and blood, selected from among LGPREKGPDP (SEQ ID NO 11), LGPREKGPDPLQ (SEQ ID NO 12), LGPREKGPDPLQY (SEQ ID NO 13), FAGLGPREKGPDP (SEQ ID NO 14), FAGLGPREKGPDPLQ (SEQ ID NO 15), FAGLGPREKGPDPLQY (SEQ ID NO 16), IDMSAFAGLGPREKGPDP (SEQ ID NO 17), IDMSAFAGLGPREKGPDPLQ (SEQ ID NO 18), IDMSAFAGLGPREKGPDPLQY (SEQ ID NO 19), and EKGPDPLQYMR (SEQ ID NO 20), which maybe useful as immunogens and antigens in cartilage resorption assays.
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