Encapsulation of bioactive agents
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United States of America Patent
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May 20, 2003
Grant Date -
Dec 5, 2002
app pub date -
May 29, 2002
filing date -
May 13, 1998
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Abstract
Bioactive agent is encapsulated in a polymer microparticle in a (water-in-oil)-in-water emulsion-based method, and using a solvent that comprises ethyl acetate. Also described are microparticles comprising low inherent viscosity (i.v.) PLG, some with i.v. less than 0.5 dl/g, and methods for their preparation. DNA release is modified through use of low i.v. PLG. A particle production method for scale-up uses a blender that avoids excessive shear damage to DNA being encapsulated.
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