Heteroaryl amidines, methylamidines and guanidines, and the use thereof as protease inhibitors
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United States of America Patent
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May 13, 2003
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N/A
app pub date -
Feb 26, 2002
filing date -
Feb 9, 1998
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Expired
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Abstract
The present invention is directed to compounds of Formula I: ##STR1## wherein X is O, S or NR.sup.7 and R.sup.1 --R.sup.7, Y and Z are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof. Also described are methods for preparing the compounds of Formula I. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, plasmin and urokinase. Certain of the compounds exhibit direct, selective inhibition of urokinase, or are intermediates useful for forming compounds having such activity.
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