Derivatives of polyene macrolides and preparation and use thereof
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United States of America Patent
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May 13, 2003
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N/A
app pub date -
Dec 20, 2001
filing date -
Jan 14, 2000
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Abstract
The present invention provides a new class of polyene macrolide derivatives useful for treating or preventing fungal infections. The new polyene macrolide derivatives exhibit surprisingly superior antifungal activity and water solubility compared to amphotericin B methyl ester (AME). In addition, the new polyene macrolide derivatives have improved water solubility and lower toxicity than both amphotericin B (AmB) and AME.
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