Process for preparing 4-substituted 1H-pyrrole-3-carboxylic acid ester
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United States of America Patent
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May 6, 2003
Grant Date -
Apr 10, 2003
app pub date -
Aug 22, 2002
filing date -
Feb 22, 2000
priority date (Note) -
Expired
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Abstract
The present invention relates to a novel process for preparing pyrrole ester compounds, which are key intermediates in the preparation of farnesyl transferase inhibitors, an anti-cancer agent Horner-Emmons reaction of aldehyde compounds provides the corresponding .alpha.,.beta.-unsaturated esters, which without any separation and/or purification steps, are treated with toluenesutfonyl-methylisocyanate in the presence of base to give pyrrole esters in one-pot fashion.
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