Compounds which inhibit leukocyte adhesion mediated by VLA-4

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United States of America Patent

PATENT NO 6559127
SERIAL NO

09127533

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Abstract

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Disclosed are compounds which bind VLA-4. Certain of these compounds also inhibit leukocyte adhesion and, in particular, leukocyte adhesion mediated by VLA-4. Such compounds are useful in the treatment of inflammatory diseases in a mammalian patient, e.g., human, such as asthma, Alzheimer's disease, atherosclerosis, AIDS dementia, diabetes, inflammatory bowel disease, rheumatoid arthritis, tissue transplantation, tumor metastasis and myocardial ischemia. The compounds can also be administered for the treatment of inflammatory brain diseases such as multiple sclerosis.

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Patent Owner(s)

Patent OwnerAddress
BIOGEN IDEC INTERNATIONAL HOLDING LTDCANON'S COURT 22 VICTORIA STREET HAMILTON HM EX

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Inventor(s)

Inventor Name Address # of filed Patents Total Citations
Dappen, Michael S Redwood City, CA 30 305
Dressen, Darren B San Mateo, CA 40 353
Grant, Francine S San Francisco, CA 43 371
Pleiss, Michael A Sunnyvale, CA 124 945
Robinson, Cynthia Y Belmont, CA 21 100
Sarantakis, Dimitrios Newtown, PA 57 394
Thorsett, Eugene D Moss Beach, CA 125 1191

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