2,3-disubstituted pyridine derivatives, process for the preparation thereof, drug compositions containing the same and intermediates for the preparation
Number of patents in Portfolio can not be more than 2000
United States of America Patent
Stats
-
Apr 29, 2003
Grant Date -
N/A
app pub date -
Mar 22, 2001
filing date -
Oct 6, 1998
priority date (Note) -
Expired
status (Latency Note)
Importance
Abstract
A compound of the formula (I) ##STR1## wherein A is O, S, CHR.sup.1 or NR.sup.2, R.sup.1 and R.sup.2 are H, lower alkyl, X.sup.1 and X.sup.2 are H, halogen, nitro, cyano, etc., Y.sup.1 is H, lower alkyl, Z.sup.1 and Z.sup.2 are H, halogen, cyano, hydroxy, lower alkyl, etc., and n is an integer of 2 to 4, a pharmaceutically acceptable salt thereof, a process for preparing the same, a pharmaceutical composition containing the same as an active ingredient, and an intermediate therefor. The compounds (I) of the present invention show a potent PDE IV inhibitory activity as well as an excellent bronchodilating activity, and hence, they are widely useful as a PDE IV inhibitor in the treatment or prophylaxis of allergic inflammatory diseases or organ inflammatory diseases, especially in the treatment or prophylaxis of pulmonary diseases accompanied by airway obstruction such as asthma.
First Claim
Family
International Classification(s)
- [Classification Symbol]
- [Patents Count]
Cited Art Landscape
Patent Citation Ranking
Recipient Email Address
Recipient Email Address
Comment
Recipient Email Address
Add to Portfolio(s)
To add this patent to one, or more, of your portfolios, simply click the add button.
This Patent is in these Portfolios:
Add to additional portfolios:
Last Refreshed On:
Changes done successfully